The ASME task group for Design by Analysis for Glassy Polymers was formed in 2019. The intent is to develop a reliable, repeatable engineering process for using transparent glassy polymers, including acrylic, in engineering applications using modern engineering methods. The current method for plastic use in pressure vessel boundaries (hulls, windows, light pipes) is currently specified an ASME PVHO-1 and is limited to the results of 1960’s empirical testing of a single polymer with a finite range of geometries. This method can be considered to be “Design By Rules” and does not allow for new shapes to be used, loads other than uniform pressure, nor does it apply material properties directly in the design the way most engineering design is done. In the current method, if the material meets the required minimums, then the resulting design is the same regardless of the actual physical properties. The Design By Analysis in current development applies the tested material properties at a given temperature in a method similar in concept to ASME Boiler and Pressure Vessel Code Section VIII, Division 2, Part 5, “Design By Analysis”. This presentation proposes the method for determining the design limit for a given application for a range of glassy polymers, with subsequent implications regarding design, in-service evaluations, and fitness-for-service for a wide range of glassy polymer applications beyond pressure vessels.